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Journal of Endodontics
Volume 46 Number 9,
, str. 1248-1255
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In this study, we studiednanobubbles(NB) Water and herssmear layerEffectiveness in removing and strengthening disinfectantsregenerated dental pulpto heal.
NB water is created in the NB generator. NB size, concentration and pH were measured. File the hog teeth to 60 gauge with a hand file and rinse with NB water or 17% waterEthylenediaminetetraoctena kiselinaor receives no further irrigation. The ability of the rinses to remove the stain layer was assessed using scanning electron microscopy (9 roots/group). Other samples (6 pieces per group) were subjected to the Vickers hardness test to determine the microhardness of dentin. autofluorescencetetracyclineMixed distilled water or NB water was placed in the root canal of pig teeth, and the depth of drug penetration into the dentinal tubules was observed with a fluorescent stereomicroscope (5 tubes/group). For disinfection experiments, human roots were prepared, autoclaved and inoculatedEnterococcus faecalis3 weeks. Then (1) standard needle irrigation (SNI) using 5.25% NaOCl, (2) using ultrasound 5.25% NaOCl (USA), (3) 5.25% NaOCl+XP Finisher (XP), (4) using 1.5% SNI for disinfection of root canals with % NaOCl, or (5) SNI with 1.5% NaOCl in NB water (5 canals/group). Teeth were cracked and stained with LIVE/DEAD backlight and visualized in the coronal, middle, and apical thirds of the root canal using confocal laser scanning microscopy (CLSM). The ratio of dead/total bacteria in dentinal tubules at different depth levels (50, 100 and 150 μm) was calculated.
NB water was more effective in removing the fouling layer than 17% EDTA and allowed tetracycline to penetrate more than 1 mm into the dentinal tubules. NB water did not change dentin microhardness compared to 17% EDTA (P<.05). At a depth of 50 μm, CLSM analysis showed no statistically significant difference between 1.5% NaOCl and 5.25% NaOCl in NB water with or without irrigation activation in the coronal, medial, and apical segments (P>.05), that is, those groups have strongerkill bacteriaMore than 1.5% NaOCl (P<.05).At deeper levels (100 and 150 μm), higher concentrations of NaOCl were more effective than 1.5% NaOCl with or without NB water. There were no statistically significant differences between 5.25% NaOCl activation with and without irrigation at most depth levels (P>.05).
NB water can remove the staining layer and improve the tubular penetration of drugs without changing the microhardness of dentin. In a large canal model, NB water appears to improve canal disinfection at low NaOCl concentrations up to 50 μm. On the other hand, activation by irrigation (US or XP) did not allow additional disinfection of dentinal tubules compared to SNI. These results suggest that NB water may be a promising adjuvantEndodontic irrigationi droge.
NB formation and characterization of water
NB water was produced using a Foamest8 nanobubble generator (Nac Corp, Seki, Japan). The NB generator consists of a pressurized gas supply housing, a nanoporous polypropylene membrane (MONOTORAN membrane [Nac Corp]), and water flowing over them. There are several nanometer pores on the membrane through which gas can pass, and the pressurized gas is released into the water in a predetermined amount through the pores. The gas expelled from the film is crushed by the diffusion force of water
Penetration of dentin tubules and removal of smear layer with NB water
The resulting NB water has a bubble size of 120 to 180 nm and a pH of 6.6-7.0. Adding NB water to a 25-gauge needle or adding NB to tetracycline had very little change in peak size, zeta potential, or number of particles/mL (Table 1). For smear removal, we found that NB water completely exposed all dentinal tubules. However, the dentin of the root canal after 1 minute of rinsing with 17% EDTA was still partially covered with a smear layer.
This research is the first report on the application and testing of NB water technology for pulp disinfection, especially in the context of improving the penetration and disinfection efficiency of endodontic drugs and irrigants used in endodontic regenerative treatments. Current irrigation protocols for pulp disinfection are limited in penetrating and disinfecting the dentinal tubules17.although this is tolerated in non-surgical endodontics because
The authors thank Nac Co, Ltd. on loan of NB generator (FOAMEST 8).
The authors deny any conflict of interest related to this study.
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Effect of preparation size on the mechanical effect of root canal irrigation in vitro
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Activation of ultrasonic irrigation during root canal treatment: a systematic review
(2019)See AlsoClustered nanobubbles, methods of formation and potential applicationsDesign of degradable nanoassemblies for the release of multiple small-sized nanoparticlesUS Patent Application for Measuring Protein Expression Using a Reagent with Barcoded Oligonucleotide Sequences (Application No. 20230125113, Issued Apr. 27, 2023)
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Chemical and ultramorphological effects of ethylenediaminetetraacetic acid and sodium hypochlorite on young and old root canal dentin
- K.Hashimototo wait.
EDTA treatment of dentine treated with sodium hypochlorite restores disrupted attachment and promotes differentiation of mouse dental papilla cells
- K.M.gridto wait.
Effects of root canal disinfection on the release of dentin growth factor
- W.Almuterito wait.
Endodontic regeneration: a systematic analysis of failure cases
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A new non-invasive model to study the effects of dentin disinfection using confocal laser scanning microscopy
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Efficacy of 4 irrigation protocols in killing dentinal tubule-colonizing bacteria investigated by novel confocal laser scanning microscopic analysis
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Vancomycin-loaded nanobubbles: a novel platform for controlled antibiotic delivery against methicillin-resistant Staphylococcus aureus infection
International Journal of Pharmacy
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Principle and application of microbubble and nanobubble technology in water treatment
Microbubble and nanobubble technology as a new horizon in water treatment technology: a review
Advanced Colloid Interface Science
Effect of residual biofilm on the release of dentin transforming growth factor β1
Concentration-dependent effects of sodium hypochlorite on the survival and differentiation of stem cells in the apical papilla
Microbial modulation of stem cells and future directions in endodontic regeneration
Sodium hypochlorite penetrates the dentin
Chemomechanical reduction of bacterial population in root canals after instrumentation and irrigation with 1%, 2.5% and 5.25% sodium hypochlorite
root canal irrigation
Quoted by (16)
Plasma Activated Microbubble Water (PMBW) deactivates and removes Klebsiella michiganii biofilm attached to internal pipe surfaces
2023, Innovative food science and new technologies
Plasma Activated Microbubble Water (PMBW) is an environmentally friendly disinfectant with strong antimicrobial activity and the ability to create significant shear stress on food contact surfaces. In this study, inoculated PVC pipes were cleaned with PMBW, plasma activated water (PAW), microbubble water (MBW) and chlorine water (100 mg/L).Klebsiella michiganiCOMSOL Multiphysics® numerically simulates the flow of a disinfectant solution with microbubbles and calculates the shear stress applied to the bacteria. The presence of microbubbles in the flow increases the shear stress applied to the bacteria. amountK. michiganensis~7.4 log CFU/cm on the inner surface of the tube2before washing. PMBW showed the strongest antimicrobial effect, reducing the number of bacteria by 3.1 log CFU/cm2At a flow speed of 1 m/s. PAW, MBW and chlorinated water reduced similar numbers of bacteria (2.4 log CFU/cm2do 2,6 log CFU/cm2) at all selected flow rates. Deionized water only reducesK. michiganensis0,7 log CFU/cm2At a flow speed of 1 m/s.
PMBW can be an environmentally friendly disinfectant that food processors can use to clean food processing equipment while minimizing the use of chemical disinfectants. The technology developed in this research will benefit the food industry by mitigating the potential risk of foodborne pathogens without creating environmental hazards.
Can Nanoscale Carriers Improve the Future of Endodontics?
2023, Overview of advanced drug delivery
Nanocarriers (NC) are dynamic nanocarriers for the delivery of biologically active derivatives such as therapeutic agents, drugs and/or dyes. The current review helps to understand the mechanism of action of several recently developed NCs with antibacterial purpose. Nine variants of NC are described here, with a focus on 19 methods described based on results obtained fromin vitroAntibacterial test. All methods have already been confirmed before, we highlighted the biochemical challenges of all NCs, and it is expected that the current data can encourage the use of NCs in basic endodontic antimicrobial research. Methodological limitations and obvious fundamental gaps prevent definitive conclusions about the optimal NC to achieve effective antimicrobial outcomes in endodontic studies. Due to the lack of preclinical studies, the number of clinical trials in this emerging field is rare, and there is still much room for improvement in several aspects.
Fundamentals and applications of nanobubbles: an overview
2023, Chemical Research and Design
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Another field of application of biomedical NB is dermatology. Nanobubbles have been reported to have anti-inflammatory (Yoshida et al., October 2020), antibacterial (Shawli et al., 2020), bactericidal (Horiuchi, 2021) and healing (Gupta and Shende, 2022) properties, so their application seems promising for various skin diseases. An interesting study by Horiuchi (Horiuchi, November 2020) showed the use of Ozone NB in the treatment of palmoplantar impetigo as an oral rinse in the periodontal area.
Nanobubble technology is a new solution for solving climate change, environmental challenges, reducing costs and energy in industrial processes, optimizing therapeutic and diagnostic techniques and other applications. Although the production and development of nanobubbles is a recently developed field, there are many reports and studies on their characteristics and promising applications in various fields. This paper aims to provide a summary of the latest (as of 2017) scientific findings on the potential of nanobubbles as a multifunctional and sustainable technology. Applications in the environment, agriculture, medicine/biomedicine and others are reviewed, and the most indicative applications in each domain are listed in detail. Special attention is paid to the implementation of water and wastewater treatment.
Effect of Monolithic Porous Ceramic Fine Bubble Scrubbing Membrane on Oil-in-Water Emulsion
In 2022, the chemical layer
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Therefore, frequent use of CEBs or immersion of membranes in chemical reagents should be avoided as this requires long downtimes and affects the efficiency of the process. In recent years, fine bubbles (FB) have attracted attention for their potential applications in water treatment as detergent-free cleaning agents, stabilizers, organism growth promoters, intracellular drug delivery, bactericidal and antimicrobial agents (Wang et al., 2021a; Yasuda and Haneda, 2015), food processing (Phan et al., 2020), agriculture (Ebina et al., 2013; Tamaki et al., 2018), fisheries (Ebina et al., 2013; Linh et al. Ljudi, 2021)) and medical industry (Cai et al., 2015; Seki et al., 2017; Shawli et al., 2020). This study focuses on the use of FB to facilitate membrane cleaning in the petroleum industry.
Produced water produced during crude oil recovery contains oil and high concentrations of salts, organics and suspended solids and therefore must be properly treated before disposal. The monolithic ceramic membrane has a high oil removal rate, compact structure, long service life, resistance to chemicals, heat and high cleaning pressure. However, membrane fouling is a significant drawback of membrane filtration. Scrubbing with air bubbles created by a diffuser is often used to physically clean membranes. However, monolithic ceramic membranes cannot be scrubbed with air bubbles because their fluid channels are only a few millimeters wide. Therefore, membrane flushing efficiency was evaluated using fine air bubbles smaller than the diameter of the channel. In blind filtration, backwashing the membrane surface with microbubble water or ultrafine bubble (UFB) water after channel backwashing and air blowing (conventional cleaning) is more effective than conventional cleaning. The leaching of UFB with water was not affected by changes in pH values that change the UFB zeta potential. Membrane fouling is suppressed in cross-flow filtration by mixing the UFB water with the feed water. There was no significant change in the diameter of oil droplets in the flow before and after mixing UFB. The ZP of the oil droplet peaks at about -20 mV before the mixing of the UFB. However, after UFB mixing, the peak shifts to around -25 to -29 mV.
Nanobubbles and nanoparticles
2021, Latest Perspectives in Colloid and Interface Science
Excerpt from the quote:
Thus, supersaturation of the dissolved gas in the mixture leads to the formation of gas bubbles and the possible nucleation of a large number of nanobubbles . Various methods have also been applied to generate large numbers of nanobubbles using the supersaturation method, including water electrolysis , temperature increase , sonication , pressure-induced supersaturation , and mechanical stirring . ]. The relationship between nanoparticles and nanobubbles is particularly interesting because it is relevant to many possible applications where both nanoparticles and nanoparticles exist.
In the last two decades, gas-saturated solutions have attracted much attention, and the existence of stable nanobubbles in solutions has been reported. The fundamental focus of interest stems from the surprising stability, which opens up a wide range of potential applications where the interaction between particles and nanobubbles is important. Here, we provide an overview of the current state of knowledge on systems involving nanobubbles and nanoparticles. Since nanoparticles and nanobubbles coexist in many situations, especially those involving the application of nanobubbles, it is important to understand these systems. This includes examining the formation of nanoparticles in nanobubbles, the nucleation of nanobubbles in nanoparticles, and the interaction between nanobubbles and nanoparticles. Clearly, further work is needed to gain a more complete understanding of these systems, especially with regard to nanobubble nucleation at submicron scales and nanobubble–nanoparticle interactions.
Insights into the September 2020 issue of the Journal of Endodontics
2020, journal of endodontics
Recommended articles (6)
Comparison of the bactericidal efficacy of sodium dichloroisocyanurate and calcium hydroxide as an intracanal drug during a 7-day contact period: an in vitro study
Journal of Endodontics, Volume 46, Number 9, 2020, Pages 1273-1278
Medicines are recommended for root canal infection. In this study, calcium hydroxide [Ca(OH)2] using engineered 3 biofilm root canal models.
Thirty-eight human single-rooted teeth were decorated and chemomechanically prepared before inoculationEnterococcus faecalis,Actinomyces viscosus, iStreptococcus mutansUse a flow cell model for 4 weeks to form a biofilm. The samples were randomly divided into 3 groups: NaDCC (n= 12), Ca(OH)2(n= 12) and positive controls (no drug,n= 14).Use the Lentulo screw to place the medicine. After 7 days of contact, the roots were crushed and planted on a selective substrate. Confirm bacterial identity using a selective medium. Calculate the colony-forming units (CFU/ml). Descriptive statistics (mean value and standard deviation) were calculated.
7-day dressing with NaDCC or Ca(OH)2no growth. For the positive control, the mean colony-forming units were 2.97E4 ± 3.42E4 (CFU/ml). All previously inoculated strains were recovered in the control group.
NaDCC i Ca(OH)2Capable of eradicating engineered 3 biofilms in single-rooted teeth when used as an endodontic agentliveModel. NaDCC deserves further study as an endodontic agent.
Anterior maxillary non-Hodgkin's lymphoma mimicking a chronic apical abscess
Journal of Endodontics, Volume 46, Number 9, 2020, Pages 1330-1336
Non-Hodgkin's lymphoma (NHL) is a malignant tumor of the lymphatic system that usually occurs between the ages of 50 and 70. Tumors develop from abnormal proliferation and accumulation of lymphocytes. Although most NHL occurs in the nodal region, 40% of cases arise in extranodal sites that include the stomach, spleen, circle of Webster, central nervous system, lung, skin, and bone. Extranodal NHL presents a diagnostic challenge because it can resemble endodontic disease when it occurs in intraosseous and soft tissues. This case report presents a misdiagnosis of diffuse large B-cell lymphoma (DLBCL) of the anterior maxilla in a 72-year-old man with a history of WM macroglobulinemia, which was thought to be related to necrotic pulp and chronic root 7 Pointed abscess. The clinical findings of the facial sinus tract, unresponsive pulp, large periapical radiolucency, and history of trauma support this diagnosis for tooth no. 7. Cone beam computed tomography and biopsy of the lesion were obtained when significant pulpal tissue was encountered during the cavity approach in tooth #7. The diagnosis of DLBCL was established by immunohistochemical and histological analysis. When evaluating lesions suspected of endodontic disease, clinicians should consider all factors including the patient's health history, genetic risk, and a comprehensive clinical examination to make a differential diagnosis. Non-dontogenic etiologies should always be considered unless otherwise excluded. Atypical presentation or tests may prompt the need for biopsy and interspecialty evaluation.
In vivo evaluation of the effect of ibuprofen on proinflammatory mediators in patients with irreversible pulpitis
Journal of Endodontics, Volume 46, Number 9, 2020, Pages 1210-1216
Preoperative use of NSAIDs has been proposed as a way to increase the effectiveness of local anesthetics and reduce postoperative pain in cases of symptomatic irreversible pulpitis. However, the role of ibuprofen at the molecular level remains unknown. Therefore, the aim of this study was to compare the levels of pro-inflammatory mediators in the dental pulp of patients who received ibuprofen preoperatively with those who did not.
Thirty-four patients with irreversible pulpitis receiving conventional endodontic treatment were randomly assigned to ibuprofen or non-ibuprofen groups. Four patients who underwent endodontic treatment for restorative reasons served as controls. Patients in the ibuprofen group were asked to take 600 mg of ibuprofen 1 hour before treatment, while patients in the non-ibuprofen and control groups were asked to refrain from using analgesics before treatment. Levels of prostaglandin E2, tumor necrosis factor α, interleukin (IL)-6, IL-1β and interferon γ were measured in blood samples obtained from dental pulp using a highly sensitive enzyme immunoassay. The postoperative pain level of each group was recorded. Data on cytokine levels and postoperative pain were analyzed using statistical analysis.
Levels of prostaglandin E2, tumor necrosis factor α, IL-6 and interferon γ were significantly lower in the ibuprofen group compared to the non-ibuprofen group. Postoperative pain levels were not significantly different between these groups.
The data showed that preoperative ibuprofen significantly reduced the levels of most pro-inflammatory cytokines in the dental pulp, which may facilitate anesthesia in irreversible cases.
Response to "Coronavirus Disease 19 (COVID-19): Impact on Clinical Dental Care"
Journal of Endodontics, Vol. 46, No. 9, 2020., str. 1342
Evaluation of mechanical root canal preparation with central reciprocal or eccentric rotational kinematics: a microcomputed tomography study
Journal of Endodontics, Volume 46, Number 9, 2020, Pages 1309-1316
The aim of this study was to compare the assessment of dentin and root canal volumes using the Reciproc system (VDW GmbH, Munich, Germany) and the XP-endo Shaper (FKG, La Chaux-de-Fonds, Switzerland) using micro-computed tomography images Changes in , percent intact wall, the volume of accumulated hard tissue remains and deviation of the root canal in the apical third.
Twenty-four mandibular molars with 2 mesial canals and one foramen were anatomically matched and divided into 2 experimental groups (n= 12) Depending on the system used. The samples were scanned before and after preparation with a microtomography scanner SkyScan 1176 (Bruker-microCT, Kontich, Belgium) at a resolution of 17.42 μm. Statistically compare the obtained data using Student at the 5% significance level.Itstest i Mann-Whitneyev test.
Significant differences were observed in intact surface area of the entire root canal, cervical spine, and middle third, with the XP-endo Shaper group having the lowest intact surface area (P< 0.05). The volume of accumulated hard tissue remains in the group receiving Reciproc was significantly higher in the entire root canal and in the middle and apical third. There were no significant differences between the groups regarding the volume of dentin removed or the increase in root canal volume and surface area (P> 0,05).
Compared to the Reciproc group, the XP-endo Shaper contacted more walls and left less hard tissue remnants in the root canal system. Although the XP-endo Shaper showed superior results, no system could fully prepare the root canal.
Insight into the April 2020 issue of the Journal of Endodontics
Journal of Endodontics, Volume 46, Number 4, 2020, Pages 453-454
Published by Elsevier Inc. on behalf of the American Association of Endodontists.